← Capillary.io team publications

Research using Capillary.io

Publications by other researchers

Explore how other research groups use Capillary.io in clinical and population studies. This collection includes applications and evaluations of the software, with links to the original publications.

Journal publications

Research articles, clinical reports and letters documenting the use of Capillary.io or its algorithms.

Letter 2026

Peripheral Capillary Rarefaction Is Associated With Cerebral Small Vessel Disease Burden: A Population-Based Study

Oscar H. Del Brutto, Denisse A. Rumbea, Robertino M. Mera, Fernando Góngora-Rivera, Eduardo J. Guzmán, Carlos Ríos, Emilio E. Arias, Víctor J. Del Brutto

Stroke. 2026;57(10):e483–e484.

Examines the relationship between nailfold capillary abnormalities and cerebral small vessel disease burden in 289 older adults from the Atahualpa cohort in Ecuador.

The corresponding preprint explicitly documents analysis with Capillary.io. This publication extends work in the same cohort as the white matter hyperintensities study listed below.

Research article 2026

Nailfold capillary phenotypes distinguish juvenile myositis subtypes and associate with disease activity

Nicholas McClellan, Li Chen, Sophia Matossian, Aurora Rynda, Kirsten Grant, Erin Janssen, J. Michelle Kahlenberg, Jessica L. Turnier

Clinical and Translational Medicine. 2026;16(9):e70789.

University of Michigan researchers used Capillary.io to detect, classify and quantify nailfold capillary features in juvenile myositis and comparison groups. The paper cites publications on the software.

Research article 2026

Habitual Oily Fish Intake and Microvascular Integrity in Frequent Fish Consumers: A Population-Based, Cross-Sectional Pilot Study

Oscar H. Del Brutto, Denisse A. Rumbea, Carlos Ríos, Emilio E. Arias, Robertino M. Mera

Journal of Primary Care & Community Health. 2026;17:21501319261473346.

A population study of 306 older adults in Ecuador examining oily fish intake and microvascular integrity. Methods explicitly name Capillary.io for automated image analysis, followed by expert review.

Letter 2026

Temporal dissociation between clinical remission and microvascular improvement assessed by AI-assisted capillaroscopy in anti–Mi-2 dermatomyositis: potential therapeutic implications

Angelo Nigro

Arthritis & Rheumatology. 2026;78(7):1557–1558.

A single-patient report using CAPI-Detect on Capillary.io for serial capillaroscopy in anti–Mi-2 dermatomyositis. It describes microvascular improvement occurring later than clinical remission and cites the platform's algorithms.

Research article 2026

Megacapillaries on nailfold capillaroscopy are associated with white matter hyperintensities burden: a population study

Oscar H. Del Brutto, Robertino M. Mera, Denisse A. Rumbea, Eduardo J. Guzmán, Carlos Ríos, Emilio E. Arias, Víctor J. Del Brutto

Journal of Stroke and Cerebrovascular Diseases. 2026;35:108633.

A study of 289 older adults in Ecuador combining nailfold capillaroscopy with brain MRI. Automated analysis used Capillary.io to quantify capillary abnormalities; the methods name the platform and link to its website.

Case report 2025

Multifactorial Induction of a “Scleroderma-Like Pattern” Without Underlying Connective Tissue Disease: Diagnostic and Therapeutic Implications

Angelo Nigro

ACR Open Rheumatology. 2025;7(1):e11784.

A case report describing a scleroderma-like capillaroscopic pattern without an underlying connective tissue disease. It explicitly uses Capillary.io and cites CAPI-Score.

A published correction updates an apical-diameter measurement in Figure 1.

Conference abstracts

Conference reports of research using or evaluating Capillary.io, published as abstracts.

Conference abstract 2026

Agreement Between Commercial Artificial Intelligence and Expert Capillaroscopist in Nailfold Capillary Density Assessment: A Two-Center Validation Study

Genessis Maldonado, Jonathan Gerwien, Ramona Govender, Maurizio Cutolo, Tracy Frech, Vanessa Smith

ACR Convergence 2026. Abstract 1686. Arthritis & Rheumatology. 2026;78(suppl 9).

A two-center evaluation comparing Capillary.io with expert capillary density assessment in 50 participants. It reports moderate overall agreement and very poor agreement at severely reduced density, and concludes that the measurements are not interchangeable with high precision.

Abstract published online for the ACR Convergence session dated 9 November 2026.

Conference abstract 2025

Capillaroscopic Signatures in Autoimmune Rheumatic Diseases: Unveiling Patterns in Systemic Sclerosis, Polyautoimmunity, and PAH

María Paula Carrillo, Juan Esteban Bedoya-Loaiza, Claudia Ibáñez-Antequera, Laura Gallego, Alejandro Escobar, Adriana Rojas-Villarraga, Jairo Cajamarca-Baron

ACR Convergence 2025. Abstract 0252. Arthritis & Rheumatology. 2025;77(suppl 9).

A Colombian study of 136 patients with autoimmune rheumatic diseases. Images acquired with Smart G-Scope were processed using Capillary.io to characterize capillaroscopic patterns.

Preprints

Manuscripts shared before peer review. The version linked here is a preprint.